Package: Rcurvep
Type: Package
Title: Concentration-Response Data Analysis using Curvep
Version: 1.2.0
Authors@R: c(person("Jui-Hua", "Hsieh", email = "juihua.hsieh@gmail.com", role = c("aut", "cre")), person("Alexander", "Sedykh", email = "sunirks@gmail.com", role = c("aut")))
Description: Provide an R interface for processing concentration-response datasets using Curvep, a response noise filtering algorithm. The algorithm was described in the publications (Sedykh A et al. (2011) <doi:10.1289/ehp.1002476> and Sedykh A (2016) <doi:10.1007/978-1-4939-6346-1_14>). Other parametric fitting approaches (e.g., Hill equation) are also adopted for ease of comparison. Also, methods for calculating the confidence interval around the activity metrics are also provided. The methods are based on the bootstrap approach to simulate the datasets (Hsieh J-H et al. <doi:10.1093/toxsci/kfy258>). The simulated datasets can be used to derive the baseline noise threshold in an assay endpoint. This threshold is critical in the toxicological studies to derive the point-of-departure (POD).
Language: en-US
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
Imports: dplyr (>= 0.7), tibble, magrittr, tidyselect, boot, tidyr,
        purrr, rlang, stringr, ggplot2, Rdpack, methods
RdMacros: Rdpack
Suggests: testthat, knitr, rmarkdown, tcpl
VignetteBuilder: knitr
RoxygenNote: 7.1.1
Depends: R (>= 3.5)
NeedsCompilation: no
Packaged: 2020-12-17 21:41:01 UTC; hsiehj2
Author: Jui-Hua Hsieh [aut, cre],
  Alexander Sedykh [aut]
Maintainer: Jui-Hua Hsieh <juihua.hsieh@gmail.com>
Repository: CRAN
Date/Publication: 2021-01-07 19:10:02 UTC
Built: R 4.0.5; ; 2022-04-21 12:16:44 UTC; windows
